Martin R B, Yeagle P L
Lipids. 1978 Sep;13(9):594-7. doi: 10.1007/BF02535821.
Three new structural models, which account for abrupt changes in physical properties observed at several molar concentrations of cholesterol in phospholipid bilayers, are described. Cholesterol monomers, each surrounded by its own envelope of unshared acyl hydrocarbon chains of the phospholipid, can accommodate 22% cholesterol. Cholesterol dimers, each surrounded by its envelope of unshared acyl hydrocarbon chains, can accommodate 31% cholesterol. When surrounded by shared acyl hydrocarbon chains, cholesterol dimmers can accommodate about 47% cholesterol. At greater concentrations, cholesterol aggregation occurs, the system is unstable, and cholesterol forms a separate phase.
描述了三种新的结构模型，它们解释了在磷脂双层中几种胆固醇摩尔浓度下观察到的物理性质的突然变化。胆固醇单体，每个都被磷脂未共享的酰基烃链包围，可容纳22%的胆固醇。胆固醇二聚体，每个都被其未共享的酰基烃链包围，可容纳31%的胆固醇。当被共享的酰基烃链包围时，胆固醇二聚体可容纳约47%的胆固醇。在更高浓度下，胆固醇会发生聚集，系统不稳定，胆固醇会形成一个单独的相。
