Doyle J A, Connolly S M, Winkelmann R K
Arch Dermatol. 1982 Nov;118(11):886-90.
Systemic scleroderma and localized scleroderma (morphea) show comparable changes on skin biopsy specimens, and a distinction has often been made on the basis of Raynaud's phenomenon, organ involvement, and laboratory abnormalities characteristically seen in systemic scleroderma. Critical evaluation not only of patients with localized scleroderma but also of those with eosinophilic fasciitis, morphea profunda, and acral pansclerotic morphea has disclosed Raynaud's phenomenon, organ involvement, and laboratory abnormalities typical of systemic scleroderma in a small percentage of patients. Histologically, all five conditions show similar inflammation and sclerosis of the skin, the primary difference being the depth at which these changes occur. These conditions may possibly be related, and the clinical and laboratory differences observed may result from variations in depth, nature, and intensity of the cutaneous and subcutaneous inflammatory sclerosis.
系统性硬化症和局限性硬皮病（硬斑病）在皮肤活检标本上呈现出相似的变化，通常根据雷诺现象、器官受累情况以及系统性硬化症特有的实验室异常来进行区分。不仅对局限性硬皮病患者，而且对嗜酸性筋膜炎、深部硬斑病和肢端全硬化性硬斑病患者进行的严格评估发现，一小部分患者存在系统性硬化症典型的雷诺现象、器官受累情况和实验室异常。从组织学上看，所有这五种情况都表现出相似的皮肤炎症和硬化，主要区别在于这些变化发生的深度。这些情况可能存在关联，观察到的临床和实验室差异可能是由于皮肤和皮下炎性硬化的深度、性质和强度不同所致。
