Kadima L N, Lesne M
Arch Int Pharmacodyn Ther. 1982 Jul;258(1):4-14.
Absorption of 3H-gitoxin and enterohepatic recirculation of the metabolites excreted in the bile were studied in the guinea-pig. Samples were assayed either by RIA or by selective counting of the radioactivity due to tritium. When administered as hydroalcoholic solutions into the stomach or into the duodenum, gitoxin is nearly completely absorbed (94.5%). But the availability of the drug in the systemic circulation is of only 35% (RIA) or 52% (CH2C12-soluble radioactivity). Only 3-5% of the metabolites excreted in the bile enter the enterohepatic cycle.
在豚鼠中研究了3H-吉他洛辛的吸收以及胆汁中排泄的代谢产物的肠肝循环。样品通过放射免疫分析（RIA）或通过对氚引起的放射性进行选择性计数来测定。当以水醇溶液形式给药到胃或十二指肠时，吉他洛辛几乎完全被吸收（94.5%）。但该药物在体循环中的利用率仅为35%（RIA）或52%（二氯甲烷可溶性放射性）。胆汁中排泄的代谢产物只有3 - 5%进入肠肝循环。
