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Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat.

作者信息

Bast A, Noordhoek J

出版信息

Biochem Pharmacol. 1982 Sep 1;31(17):2745-53. doi: 10.1016/0006-2952(82)90128-9.

DOI:10.1016/0006-2952(82)90128-9
PMID:7138571
Abstract
摘要

相似文献

1
Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat.氯苯那敏及其代谢产物与大鼠肝脏微粒体细胞色素P-450氧化态和还原态的光谱相互作用。
Biochem Pharmacol. 1982 Sep 1;31(17):2745-53. doi: 10.1016/0006-2952(82)90128-9.
2
Product inhibition in orphenadrine metabolism as a result of a stable cytochrome P-450-metabolic intermediate complex formed during the disposition of mono-N-desmethylorphenadrine (tofenacine) in the rat.在大鼠体内单-N-去甲基邻甲苯海明（托非那辛）代谢过程中形成稳定的细胞色素P-450代谢中间复合物，导致邻甲苯海明代谢出现产物抑制现象。
Res Commun Chem Pathol Pharmacol. 1983 Jun;40(3):391-403.
3
Inhibition of oxidative drug metabolism by orphenadrine: in vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics.奥芬那君对氧化药物代谢的抑制作用：细胞色素P-450同工酶特异性络合及抑制动力学的体外和体内证据
Mol Pharmacol. 1989 May;35(5):736-43.
4
Relationship between molecular structure and cytochrome P450-metabolic intermediate complex formation, studied with orphenadrine analogues.用邻苯海拉明类似物研究分子结构与细胞色素P450代谢中间复合物形成之间的关系。
J Pharm Sci. 1984 Jul;73(7):953-6. doi: 10.1002/jps.2600730723.
5
Evidence for complexation of P-450 IIC6 by an orphenadrine metabolite.
Biochem Biophys Res Commun. 1990 Jan 30;166(2):772-9. doi: 10.1016/0006-291x(90)90876-o.
6
Spectral interaction between 4-methylphenol and beta-oestradiol on hepatic microsomal cytochrome P-450: difference between ethanol and phenobarbital pretreatment.4-甲基苯酚与β-雌二醇在肝微粒体细胞色素P-450上的光谱相互作用：乙醇和苯巴比妥预处理之间的差异
Pharmacol Toxicol. 1987 May;60(5):399-400. doi: 10.1111/j.1600-0773.1987.tb01536.x.
7
Metabolite complex formation of orphenadrine with cytochrome P450. Involvement of CYP2C11 and CYP3A isozymes.奥芬那君与细胞色素P450的代谢物复合物形成。CYP2C11和CYP3A同工酶的参与。
Biochem Pharmacol. 1996 Jul 12;52(1):73-84. doi: 10.1016/0006-2952(96)00140-2.
8
Interaction of nitromethane with reduced hepatic microsomal cytochrome P-450.硝基甲烷与还原型肝微粒体细胞色素P-450的相互作用。
Biochem Pharmacol. 1977 May 15;26(10):963-7. doi: 10.1016/0006-2952(77)90475-0.
9
Interaction of constitutive and phenobarbital-induced cytochrome P-450 isozymes during the sequential oxidation of benzphetamine. Explanation for the difference in benzphetamine-induced hydrogen peroxide production and 455-nm complex formation in microsomes from untreated and phenobarbital-treated rats.苯丙胺连续氧化过程中组成型和苯巴比妥诱导的细胞色素P-450同工酶的相互作用。对未处理和苯巴比妥处理大鼠微粒体中苯丙胺诱导的过氧化氢产生和455纳米复合物形成差异的解释。
Mol Pharmacol. 1983 May;23(3):748-57.
10
Tetrachloroethylene metabolism by the hepatic microsomal cytochrome P-450 system.四氯乙烯通过肝脏微粒体细胞色素P-450系统进行代谢。
Biochem Pharmacol. 1980 Oct 15;29(20):2863-9. doi: 10.1016/0006-2952(80)90023-4.

引用本文的文献

1
Upregulation of cytochromes P450 2B in rat liver by orphenadrine.邻苯海明对大鼠肝脏细胞色素P450 2B的上调作用。
Br J Pharmacol. 2003 Jun;139(4):787-96. doi: 10.1038/sj.bjp.0705305.
2
Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat.多次给予奥芬那君或单-N-去甲基奥芬那君对大鼠细胞色素P-450催化反应的影响。
Arch Toxicol. 1983 Oct;54(2):131-7. doi: 10.1007/BF01261381.
3
Dependence of hydrogen peroxide formation in rat liver microsomes on the molecular structure of cytochrome P-450 substrates: a study with barbiturates and beta-adrenoceptor antagonists.
大鼠肝微粒体中过氧化氢生成对细胞色素P-450底物分子结构的依赖性：巴比妥类药物和β-肾上腺素能受体拮抗剂的研究
Eur J Drug Metab Pharmacokinet. 1989 Apr-Jun;14(2):93-100. doi: 10.1007/BF03190847.
4
Cytochrome P-450 metabolic-intermediate complex formation with a series of diphenhydramine analogues.细胞色素P-450与一系列苯海拉明类似物形成代谢中间复合物。
Agents Actions. 1990 Apr;30(1-2):161-5. doi: 10.1007/BF01969027.