Sims F H
Med Hypotheses. 1978 Jul-Aug;4(4):388-400. doi: 10.1016/0306-9877(78)90074-9.
The limitations of current theories of the mechanism of intimal thickening in arteriosclerosis are briefly reviewed. The suggestion is advanced that this change is due to intimal oedema, arising from failure of the lymphatic system of the surrounding tissue to remove adequately, protein-containing fluid filtering outwards through the vascular endothelium. It is postulated that such local environmental influences account for the variability in the degree of arterial degeneration seen in different arteries, and in different portions of the same artery.
本文简要回顾了当前关于动脉硬化内膜增厚机制理论的局限性。有人提出，这种变化是由于内膜水肿所致，内膜水肿源于周围组织淋巴系统无法充分清除通过血管内皮向外滤出的含蛋白质液体。据推测，这种局部环境影响解释了在不同动脉以及同一动脉不同部位所见动脉退变程度的差异。
