普萘洛尔作为精神分裂症治疗的辅助药物。

Propranolol as an adjunct to the treatment of schizophrenia.

作者信息

Yorkston N J, Zaki S A, Pitcher D R, Gruzelier J H, Hollander D, Sergeant H G

出版信息

Lancet. 1977 Sep 17;2(8038):575-8. doi: 10.1016/s0140-6736(77)91427-1.

Abstract

Propranolol contributed usefully to the practical management of patients with chronic schizophrenia whose florid symptoms had not remitted with major tranquillisers. 14 patients who had received an average equivalent of 954 mg per day of chlorpromazine for 10 years were given, in addition, either propranolol or a placebo for 12 weeks. Both groups had improved by the twelfth week, but the propranolol group had improved significantly more.

摘要

对于那些严重症状未因使用大剂量镇静剂而缓解的慢性精神分裂症患者，普萘洛尔在实际治疗中发挥了有益作用。14名平均每天服用相当于954毫克氯丙嗪达10年之久的患者，另外接受了为期12周的普萘洛尔或安慰剂治疗。到第12周时，两组患者的病情均有改善，但普萘洛尔组的改善更为显著。