饱和磷脂酰乙醇胺和磷脂酰胆碱双层膜性质的比较研究：屏障特性及对磷脂酶A2降解的敏感性

Comparative study on the properties of saturated phosphatidylethanolamine and phosphatidylcholine bilayers: barrier characteristics and susceptibility to phospholipase A2 degradation.

作者信息

Noordam P C, Killian A, Oude Elferink R F, De Gier J

出版信息

Chem Phys Lipids. 1982 Oct;31(2):191-204. doi: 10.1016/0009-3084(82)90044-5.

Abstract

comparative studies on bilayer systems of saturated phosphatidylcholines and phosphatidylethanolamines revealed a maximum in ionic permeability in phosphatidylcholine bilayers at the temperature of the gel to liquid-crystalline phase transition but such an increase in permeability was not detectable in bilayers of phosphatidylethanolamine. Furthermore, it was found that at the phase transition temperature the phosphatidylcholine bilayers are subject to rapid hydrolysis by pancreatic phospholipase A2 whereas phosphatidylethanolamine bilayers are not. These differences are discussed in view of detailed information on the molecular organization in the gel and liquid crystalline phases of the two phospholipid classes.

摘要

对饱和磷脂酰胆碱和磷脂酰乙醇胺双层系统的比较研究表明，在凝胶态到液晶态相变温度下，磷脂酰胆碱双层的离子通透性出现最大值，但在磷脂酰乙醇胺双层中未检测到这种通透性增加。此外，还发现，在相变温度下，磷脂酰胆碱双层会被胰磷脂酶A2迅速水解，而磷脂酰乙醇胺双层则不会。根据这两类磷脂在凝胶相和液晶相分子组织的详细信息，对这些差异进行了讨论。