Cheng N, Van Hoof H, Bockx E, Hoogmartens M J, Mulier J C, De Dijcker F J, Sansen W M, De Loecker W
Clin Orthop Relat Res. 1982 Nov-Dec(171):264-72.
Direct electric currents ranging from 10 microA to 1000 microA increase ATP concentrations in the tissue and stimulate amino acid incorporation into the proteins of rat skin. The amino acid transport through the cell membrane, followed by the alpha-aminoisobutyric acid uptake, is stimulated between 100 microA and 750 microA. The stimulatory effects on ATP production and on amino acid transport, apparently mediated by different mechanisms, contribute to the final increased protein synthesizing activity. DNA metabolism followed by thymidine incorporation remains unaffected during the course of current application. The effects on AtP production can be explained by proton movements on the basis of the chemiosmotic theory of Mitchell, while the transport functions are controlled by modification in the electrical gradients across the membranes.
强度范围在10微安至1000微安之间的直流电可提高组织中的ATP浓度，并刺激氨基酸掺入大鼠皮肤的蛋白质中。在100微安至750微安之间，氨基酸通过细胞膜的转运（随后是α-氨基异丁酸的摄取）会受到刺激。对ATP生成和氨基酸转运的刺激作用显然由不同机制介导，它们共同促成了最终蛋白质合成活性的提高。在施加电流的过程中，DNA代谢以及随后的胸苷掺入不受影响。根据米切尔的化学渗透理论，对ATP生成的影响可以通过质子运动来解释，而转运功能则由跨膜电势梯度的改变来控制。
