Wood B A, Tortoledo F, Luck J C, Fennell W H
Chest. 1982 Dec;82(6):793-4. doi: 10.1378/chest.82.6.793.
In a 22-year-old woman with primary pulmonary hypertension resistant to all previous attempts to reduce the pulmonary vascular resistance, there was dramatic improvement after the first dose of nifedipine, 20 mg po, which was not sustained with subsequent doses. While there was a persistent reduction in systemic vascular resistance, the initial drug-related reduction in pulmonary vascular resistance was progressively attenuated with the subsequent four doses of nifedipine, 20 mg.
一名22岁女性患有原发性肺动脉高压，此前所有降低肺血管阻力的尝试均无效。在口服20毫克硝苯地平首剂后，病情显著改善，但后续剂量未能维持这一效果。虽然全身血管阻力持续降低，但随后四剂20毫克硝苯地平使最初与药物相关的肺血管阻力降低逐渐减弱。
