Pathogenesis on the experimental infections of Candida albicans in chickens.

Systemic candidiasis were induced in chickens by both intravenous and subcutaneous injections of viable Candida albicans. However, infection was not encountered by intratracheal or oral injections. Pathologically, necrotic foci were found in the brain, heart, and spleen but not in the liver, kidney and lungs of the diseased chickens. Numerous segments of the pseudomycelium were seen in the necrotic areas which were surrounded by foreign body giant cells. Pure cultures of the agent were successfully isolated from the necrotic tissues. C albicans seemed to have an affinity for the brain and heart in chickens instead of the kidney which is focus of infections in rabbits.