Klein H O, Wickramanayake P D, Dieterle F, Mohr R, Oerkermann H, Brock J, Beyer D, Gross R
Dtsch Med Wochenschr. 1982 Nov 12;107(45):1708-12. doi: 10.1055/s-2008-1070192.
The possible effectiveness of methotrexate, 5-fluorouracil and adriamycin was tested in a phase I/II study of patients with metastasising gastric carcinoma. complete of partial remission occurred in 19 of 30 patients (approximately 63%). Two of 30 patients had complete remission. Median survival time of patients with remission cannot as yet be determined: about 68% are still alive after 17 months. Median survival time of patients with advanced tumour was only five months. The difference in survival curve is statistically significant (P less than 0.05). The study is continuing.
在一项针对转移性胃癌患者的I/II期研究中，对甲氨蝶呤、5-氟尿嘧啶和阿霉素的潜在疗效进行了测试。30名患者中有19名（约63%）出现完全或部分缓解。30名患者中有2名完全缓解。缓解患者的中位生存时间尚未确定：17个月后约68%的患者仍存活。晚期肿瘤患者的中位生存时间仅为5个月。生存曲线的差异具有统计学意义（P小于0.05）。该研究仍在继续。
