Goodfellow P N, Banting G, Wiles M V, Tunnacliffe A, Parkar M, Solomon E, Dalchau R, Fabre J W
Eur J Immunol. 1982 Aug;12(8):659-63. doi: 10.1002/eji.1830120807.
The monoclonal antibody, F10.44.2, is directed against a human antigenic determinant of restricted tissue distribution. In this report it is shown that this determinant is coded for by a gene, MIC4, which is on human chromosome 11, as shown by its reactivity with a panel of somatic cell hybrids. Synteny with an antigen recognized by another monoclonal antibody, W6/34, is demonstrated by hybrid and fluorescence-activated cell sorter analysis, although it is clear from absorption analysis that the determinants involved are on different molecules.
单克隆抗体F10.44.2针对一种组织分布受限的人类抗原决定簇。本报告表明，该决定簇由位于人类11号染色体上的MIC4基因编码，这通过其与一组体细胞杂种的反应得以证明。通过杂种和荧光激活细胞分选分析证明了与另一种单克隆抗体W6/34识别的抗原存在同线性，尽管从吸收分析中清楚地看出所涉及的决定簇位于不同分子上。
