Mullane K M, Bradley G, Moncada S
Eur J Pharmacol. 1982 Oct 15;84(1-2):115-8. doi: 10.1016/0014-2999(82)90166-2.
The interactions of 5-hydroxytryptamine (5-HT) and a thromboxane A2 mimetic, U44069, were investigated on rings of canine coronary arteries. 5-HT (10(-8) - 10(-5) M) and U44069 (10(-9) - 10(-6) M) produce coronary vasoconstriction which is potentiated by indomethacin (3 X 10(-6) M). In the presence of 10(-9) M 5-HT, U44069-induced vasoconstriction is enhanced. Similarly, 10(-9) M U44069 enhances the effects of 5-HT. In both cases this potentiation is greatest in the presence of indomethacin. Synergism between the platelet-derived mediators could contribute to coronary vasospasm and myocardial ischaemia.
研究了5-羟色胺（5-HT）与血栓素A2类似物U44069对犬冠状动脉环的相互作用。5-HT（10⁻⁸ - 10⁻⁵ M）和U44069（10⁻⁹ - 10⁻⁶ M）可引起冠状动脉收缩，吲哚美辛（3×10⁻⁶ M）可增强这种收缩作用。在存在10⁻⁹ M 5-HT的情况下，U44069诱导的血管收缩增强。同样，10⁻⁹ M U44069可增强5-HT的作用。在这两种情况下，这种增强作用在吲哚美辛存在时最为明显。血小板衍生介质之间的协同作用可能导致冠状动脉痉挛和心肌缺血。
