Richter-Reichhelm H B, Schmidt-Riese L, Emura M, Althoff J
Exp Pathol. 1982;22(2):67-71. doi: 10.1016/s0232-1513(82)80027-3.
The transplacental effect of vinylethylnitrosamine (VEN) on the respiratory epithelium of Syrian golden hamsters was tested after administration of 5 and 10 mg VEN/kg b.w. dissolved in olive oil at the 12th or 15th day of gestation. The morphological data, obtained mainly by scanning electron microscopy on tracheae revealed metaplastic and hyperplastic epithelial changes, as well as focal exophytic papillary proliferations at the 30th postnatal day in the group treated at the 15th day of gestation. No comparable lesions were found in the trachea of the F1 generation when mothers were treated with VEN at day 12 of pregnancy or in animals of the control group (olive oil only). The biological effects of VEN after transplacental exposure were compared to those of other nitrosamines.
在妊娠第12天或第15天，给叙利亚金黄地鼠腹腔注射溶解于橄榄油中的5毫克/千克体重和10毫克/千克体重的乙烯基乙基亚硝胺（VEN），以测试其经胎盘对叙利亚金黄地鼠呼吸道上皮的影响。主要通过扫描电子显微镜对气管进行观察获得的形态学数据显示，在妊娠第15天接受治疗的组中，出生后第30天气管出现化生和增生性上皮变化，以及局灶性外生性乳头状增生。当母亲在妊娠第12天接受VEN治疗时，F1代气管中未发现类似病变，对照组动物（仅注射橄榄油）也未发现类似病变。将经胎盘暴露后VEN的生物学效应与其他亚硝胺的效应进行了比较。
