Vasin M V, L'vova T S, Dobrov N N, Koroleva L V, Semenova L A
Farmakol Toksikol. 1982 Sep-Oct;45(5):71-3.
Normobaric hyperoxia upon breathing pure oxygen for 20 and 120 min is capable to produce in (CBA X S57B1)F1 mice a short-term (up to 1 day) cytostatic action on bone marrow tissues. Under the same conditions oxygen reduced proliferative activity in duodenal crypts by the 3rd and 6th days of the experiment. Changes in the morphological composition of the blood manifesting in the increased counts of leukocytes, neutrophiles, eosinophiles and monocytes are physiological and compensatory in nature.
在(CBA×S57B1)F1小鼠中,呼吸纯氧20分钟和120分钟的常压高氧能够对骨髓组织产生短期(长达1天)的细胞抑制作用。在相同条件下,到实验第3天和第6天,氧气降低了十二指肠隐窝中的增殖活性。血液形态组成的变化表现为白细胞、中性粒细胞、嗜酸性粒细胞和单核细胞数量增加,本质上是生理性和代偿性的。