Maekawa A, Takahashi M, Kurokawa Y, Kokubo T, Ogiu T, Odashima S, Mochizuki M, Anjo T, Okada M
IARC Sci Publ. 1982(41):619-24.
The carcinogenicity of eleven alpha-oxidized nitrosamines (alpha-acyloxy, alpha-hydroperoxy and alpha-oxo nitrosamines) was tested in F-344 rats. All chemicals were dissolved in olive oil and rats received 10 weekly subcutaneous injections of these chemicals (10 x 5 mg/kg of N-methyl-N-(acetoxymethyl) nitrosamine or equimolar amounts of the other chemicals) at the interscapular region. Subcutaneous tumours were detected in many rats of all groups treated with the chemicals, although no tumour was detected at the injection site in the control group. Lung and thyroid tumours were also observed in many rats of the treated groups, especially those injected with N-alkyl-N-(acetoxymethyl)nitrosamines. Many other tumours developed in the experimental groups, but it is not certain that they were related to the treatment with the chemicals. The results indicate that the chemicals possess local as well as systemic carcinogenicity in F-344 rats. The potent carcinogenic effects at the injection site of the alpha-oxidized nitrosamines, coupled with their direct mutagenic activity, suggest that these derivatives are useful models for the ultimate form of the metabolically activated nitrosamines.
在F-344大鼠中测试了11种α-氧化亚硝胺（α-酰氧基、α-氢过氧基和α-氧代亚硝胺）的致癌性。所有化学物质均溶于橄榄油，大鼠在肩胛间区域每周皮下注射10次这些化学物质（10×5mg/kg的N-甲基-N-（乙酰氧甲基）亚硝胺或等摩尔量的其他化学物质）。在所有接受化学物质治疗的组中的许多大鼠中都检测到了皮下肿瘤，尽管在对照组的注射部位未检测到肿瘤。在治疗组的许多大鼠中也观察到了肺和甲状腺肿瘤，尤其是那些注射了N-烷基-N-（乙酰氧甲基）亚硝胺的大鼠。在实验组中还出现了许多其他肿瘤，但不确定它们是否与化学物质治疗有关。结果表明，这些化学物质在F-344大鼠中具有局部和全身致癌性。α-氧化亚硝胺在注射部位的强效致癌作用，加上它们的直接诱变活性，表明这些衍生物是代谢活化亚硝胺最终形式的有用模型。
