Pathak J D, Joshi S V
Indian J Physiol Pharmacol. 1982 Apr-Jun;26(2):125-9.
Renal efficiency of 70 healthy subjects, 20 young av. age 27.2 +/- 5.8 yrs and 60 elderly av. age 68.2 +/- 4.7 yrs was studied by simple water elimination test in the monitoring under standard conditions. After drinking 2 litre of water, hourly samples of urine upto 4 hrs were collected for volume, sp. gr. urea, creatinine etc. The younger group passed 77% of the extra water drunk in 2 hrs and 92.5% in 4 hrs, whereas the elderly could throw out only 33% in 2 hrs and 56% in 4 hrs. The elderly showed much delayed and poorer elimination. The sp. gr., urea and creatinine in each sample of urine were less in the old indicating their inefficient elimination ability. Av. blood urea was 20.2 +/- 3.8 mg+ in young and 25.4 +/- 7.0 mg% in elderly, respectively. Calculated av. urea clearance value was 61.3 ml/mt in the young, while it was 39.4 ml/mt in the elderly. How well this simple test reflects the decreasing renal efficiency on ageing and compares with more elaborate tests like urea clearance is discussed.
在标准条件监测下，通过简单的排水试验研究了70名健康受试者的肾脏效率，其中20名年轻人平均年龄为27.2±5.8岁，60名老年人平均年龄为68.2±4.7岁。饮用2升水后，每小时收集尿液样本，持续4小时，检测尿量、比重、尿素、肌酐等指标。年轻组在2小时内排出了摄入额外水分的77%，4小时内排出了92.5%，而老年人在2小时内仅排出33%，4小时内排出56%。老年人的排泄明显延迟且较差。老年人尿液样本中的比重、尿素和肌酐含量较低，表明其排泄能力低下。年轻人的平均血尿素为20.2±3.8毫克%，老年人为25.4±7.0毫克%。计算得出年轻人的平均尿素清除率为61.3毫升/分钟，而老年人为39.4毫升/分钟。本文讨论了这项简单测试如何很好地反映衰老过程中肾脏效率的下降，以及与尿素清除率等更复杂测试的比较情况。
