Gethmann U, Ball P
Hautarzt. 1982 Aug;33(8):424-7.
In ten of 12 patients with non-progressive hirsutism a pathologic pattern of androgens was assessed by hormone determinations. Using a new test procedure increased androgen production could be tentatively associated with an impaired function of either ovaries or adrenals. Androgen-producing tumors could be excluded. With differential therapy (progestins, estrogens, corticosteroids, antiandrogens) pathologic androgen serum levels subsided already prior to antiandrogen medication. Definite clinical success was, however, observed only it antiandrogen therapy. As long-term therapy a low-dose antiandrogen-estrogen combination proved valuable.
在12例非进行性多毛症患者中的10例中,通过激素测定评估了雄激素的病理模式。采用一种新的检测方法,雄激素生成增加可能暂时与卵巢或肾上腺功能受损有关。可以排除产生雄激素的肿瘤。采用差异疗法(孕激素、雌激素、皮质类固醇、抗雄激素),在使用抗雄激素药物之前,病理性雄激素血清水平就已下降。然而,仅在抗雄激素治疗中观察到明确的临床疗效。作为长期治疗,低剂量抗雄激素 - 雌激素联合治疗被证明是有价值的。