Slayton R E
Int J Radiat Oncol Biol Phys. 1982 Aug;8(8):1431-4. doi: 10.1016/0360-3016(82)90595-8.
A small number of women with metastatic ovarian cancer can now be cured with cytotoxic agents. The majority, however, succumb and die. To aid in the search for new and more effective agents the National Cancer Institute has developed a preclinical screening program using human tumor xenografts in nude mice in addition to the more traditional experimental animal tumors. A number of cancer centers and cooperative clinical groups have developed programs for human trials. The recent development of an ovarian cancer clonogenic assay may provide an additional in vitro method for identifying useful new drugs specifically directed against ovarian cancer.
少数转移性卵巢癌女性患者现在可以通过细胞毒性药物治愈。然而，大多数患者会死亡。为了协助寻找新的、更有效的药物，美国国立癌症研究所除了使用更传统的实验动物肿瘤外，还开发了一种在裸鼠中使用人肿瘤异种移植物的临床前筛查程序。一些癌症中心和合作临床组已经制定了人体试验计划。卵巢癌克隆形成试验的最新进展可能会提供另一种体外方法，用于识别专门针对卵巢癌的有用新药。
