一种新型氨基糖苷类抗生素：西索米星的药代动力学及临床研究
[Pharmacokinetic and clinical research on a new aminoglycoside antibiotic: sisomicin].
作者信息
Di Nola F, Soranzo M L, Bosio G, Sachelariu N, Guasco C, Bendiscioli L, Bisarello I
出版信息
Minerva Med. 1978 Sep 19;69(43):2951-62.
PMID:714275
Abstract
Results obtained with sisomycin in 10 cases of purulent meningitis and 4 of bronchopulmonitis showed good tissue diffusion, together with CSF concentrations sufficient to inhibit the main aetiological agents in these forms: MIC 0.02 mg/ml for both D. pneumoniae (I-ATCC 6301) and N. meningitidis (C-ATCC 13101), i.e. liquor transfer of the antibiotic more than sufficient to handle these agents.
摘要
西索米星在10例化脓性脑膜炎和4例支气管肺炎患者中的治疗结果显示，该药在组织中扩散良好，脑脊液浓度足以抑制这些疾病的主要病原体：肺炎链球菌（I-ATCC 6301）和脑膜炎奈瑟菌（C-ATCC 13101）的最低抑菌浓度均为0.02mg/ml，即抗生素在脑脊液中的转移量足以有效应对这些病原体。
Zotero 插件