Cowan M J, Reichenbach D D, Bruce R A, Fisher L
J Electrocardiol. 1982 Oct;15(4):307-16. doi: 10.1016/s0022-0736(82)81002-9.
This study described the linear relationship of the myocardial infarct size, measured postmortem, to the integral of the sequential vector spatial magnitudes analyzed at 400 samples per second during the initial period of abnormal depolarization (IAD) in 25 patients with myocardial infarction (MI) and ten controls. The equation for the fitted regression line was: %MI = -0.35 + 3.33 IAD; r = .90; p less than .001. The duration of abnormal depolarization was determined by two computer algorithms: first, using the classical method of pathological Q wave duration, whenever possible; and a new method of measurement of an abnormally slow rate of rise of vector spatial magnitude with time (dm/dt), when there were no Q waves in the Frank orthogonal lead input signals. There was not a significant difference in the mean values of IAD of the MI group or the control group calculated by the two algorithms.
本研究描述了25例心肌梗死（MI）患者和10例对照者在异常去极化初始期（IAD）每秒400次采样时分析的连续向量空间幅度积分与死后测量的心肌梗死面积之间的线性关系。拟合回归线方程为：%MI = -0.35 + 3.33 IAD；r = 0.90；p < 0.001。异常去极化持续时间由两种计算机算法确定：首先，尽可能采用病理性Q波持续时间的经典方法；当Frank正交导联输入信号中没有Q波时，采用一种测量向量空间幅度随时间异常缓慢上升速率（dm/dt）的新方法。两种算法计算的MI组或对照组IAD平均值无显著差异。
