Kása P, Bánsághy K, Rakonczay Z, Gulya K
J Neurochem. 1982 Dec;39(6):1726-32. doi: 10.1111/j.1471-4159.1982.tb08009.x.
The components of the cholinergic nervous system, i.e., choline acetyltransferase, acetylcholinesterase, sodium-dependent high-affinity choline uptake, acetylcholine, and the muscarinic acetylcholine receptors, in the developing archi- and paleocerebellum of the rat have been investigated by biochemical methods. A close correlation between the development of the different elements of the system has been demonstrated in the two areas. The cholinergic structure develops first in the archicerebellum, which displays high levels of choline acetyltransferase, acetylcholinesterase, acetylcholine, and sodium-dependent high-affinity choline uptake. The paleocerebellum receives a sparser cholinergic innervation during development. The differences in the values for these components in the cerebellum as a whole may reflect the development of cholinergic and noncholinergic neuronal structures. It is concluded that the development of the cholinergic system cannot be analyzed in the cerebellum as a whole; rather specific regions such as the archi-, paleo-, or neocerebellum must be examined.
采用生化方法对大鼠发育中的原小脑和旧小脑中胆碱能神经系统的组成成分，即胆碱乙酰转移酶、乙酰胆碱酯酶、钠依赖性高亲和力胆碱摄取、乙酰胆碱和毒蕈碱型乙酰胆碱受体进行了研究。在这两个区域中，已证明该系统不同成分的发育之间存在密切相关性。胆碱能结构首先在原小脑中发育，原小脑显示出高水平的胆碱乙酰转移酶、乙酰胆碱酯酶、乙酰胆碱和钠依赖性高亲和力胆碱摄取。旧小脑在发育过程中接受的胆碱能神经支配较为稀疏。整个小脑中这些成分的值的差异可能反映了胆碱能和非胆碱能神经元结构的发育情况。得出的结论是，不能在整个小脑中分析胆碱能系统的发育；相反，必须检查诸如原小脑、旧小脑或新小脑等特定区域。
