Giesecke W H
Onderstepoort J Vet Res. 1978 Jun;45(2):107-18.
Eight different mastitis remedies were administered intracisternally on a rotational basis to the 48 quarters of 12 mastitis negative cows. The resulting intramammary reactions were monitored by determining the Somatic Cell Count (SCC) and Bovine Serum Albumin (BSA) levels in milk. The reactions observed indicate that the intramammary cellular reactions frequently elicited by the local treatments in the treated and sometimes even in the untreated quarters of the treated udders are not necessarily inflammatory in nature. Evaluation of the intramammary tissue compatibility of a mastitis remedy mainly in terms of SCC values therefore seems unreliable. Moreover, it may do injustice to a product unless the SCC values are augmented by BSA or other determinations providing a more accurate indication of truly mastitic reactions. The investigation also implies that the patterns of cellular reactions related to individual mastitis remedies require further elucidation before they can be used as indications of an advantageous or disadvantageous intramammary tissue compatibility of a product. Intramammary tissue compatibility, as such, of mastitis remedies and comparable agents requires definition. It seems more expedient, however, that such a definition and the necessary standardization of mastitis remedies in terms of their intramammary tissue compatibility be attempted by the International Dairy Federation (IDF).
对12头无乳腺炎奶牛的48个乳腺进行了8种不同的乳腺炎治疗方法的轮次乳池内给药。通过测定牛奶中的体细胞计数（SCC）和牛血清白蛋白（BSA）水平来监测由此产生的乳腺内反应。观察到的反应表明，在接受治疗的乳腺的治疗乳腺以及有时甚至未治疗的乳腺中，局部治疗频繁引发的乳腺内细胞反应本质上不一定是炎症性的。因此，主要根据SCC值来评估乳腺炎治疗方法的乳腺内组织相容性似乎并不可靠。此外，除非SCC值通过BSA或其他能更准确指示真正乳腺炎反应的测定来补充，否则可能对产品不公平。该研究还表明，在将与个体乳腺炎治疗方法相关的细胞反应模式用作产品乳腺内组织相容性有利或不利的指标之前，需要进一步阐明。乳腺炎治疗方法及类似制剂的乳腺内组织相容性本身需要进行定义。然而，由国际乳品联合会（IDF）尝试对乳腺炎治疗方法的这种定义及其乳腺内组织相容性进行必要的标准化似乎更为适宜。
