De Vos A J
Onderstepoort J Vet Res. 1978 Jun;45(2):119-24.
A strain of Babesia bovis, which has been routinely used in the locally produced babesiosis vaccine for two decades and maintained by needle passage, was of low virulence and therefore safe, but it induced poor protection to challenge with two field isolates. Animals infected with this attenuated strain and subsequently challenged heterologously with a field strain were solidly immune when challenged later with a 2nd field strain. The two field strains, though more virulent, conferred a high degree of immunity to heterologous challenge.
一种牛巴贝斯虫菌株，二十年来一直用于当地生产的巴贝斯虫病疫苗，并通过针刺传代进行保存，其毒力较低，因此是安全的，但它对两种野外分离株的攻击诱导的保护效果不佳。感染这种减毒株的动物，随后用一种野外菌株进行异源攻击，当后来用第二种野外菌株攻击时，具有稳固的免疫力。这两种野外菌株虽然毒力更强，但对异源攻击具有高度免疫力。
