四氧嘧啶糖尿病大鼠心脏周期的迷走神经控制

Vagal control of heart period in alloxan diabetic rats.

作者信息

Stuesse S L, Wallick D W, Mace S

出版信息

Life Sci. 1982 Jul 26;31(4):393-8. doi: 10.1016/0024-3205(82)90420-9.

Abstract

Autonomic neuropathies are a frequent complication to diabetes in humans. Similar neuropathies have not been well-documented in animal models. To determine if diabetic rats would develop parasympathetic neuropathies, rats were made diabetic by the injection of alloxan into the tail vein and then maintained on daily injections of insulin. At various times subsequent to the induction of diabetes (3-5 weeks, 7-9 weeks, and 14 weeks), the effect of constant frequencies of vagal stimulation on the efferent cardiac chronotropic response was evaluated using analysis of variance techniques. It was found that the vagal parasympathetic effect was accentuated in diabetic rats. That is, at a given frequency of supramaximal vagal stimulation, the heart rate slowed more in diabetic rats than in nondiabetic rats. Whether a similar phenomenon exists in humans is not known.

摘要

自主神经病变是人类糖尿病常见的并发症。类似的神经病变在动物模型中尚未得到充分记录。为了确定糖尿病大鼠是否会发生副交感神经病变，通过向尾静脉注射四氧嘧啶使大鼠患糖尿病，然后每天注射胰岛素维持。在诱导糖尿病后的不同时间（3 - 5周、7 - 9周和14周），使用方差分析技术评估恒定频率的迷走神经刺激对传出性心脏变时反应的影响。结果发现，糖尿病大鼠的迷走神经副交感效应增强。也就是说，在给定的超最大迷走神经刺激频率下，糖尿病大鼠的心率比非糖尿病大鼠减慢得更多。人类是否存在类似现象尚不清楚。