Hancock R L
Med Hypotheses. 1982 Aug;9(2):229-40. doi: 10.1016/0306-9877(82)90140-2.
In this paper an extension of prior writings on the mechanism by which changes in genic expression is presented. The previous development of these ideas led to a unifying concept of alterations in heterochromatin due to a variety of carcinogenic agents as a pivital process leading to potential re-expressions of genes (1). The following deals just with structural features of chromatin before continuing to finer control levels of gene expression, especially in reference to cancer cells. The DNA methylation status is presented as being an important step in an intermediate stage of chromatin expression along with protein acetylation, phosphorylation and methylation as other means of modifying chromatin status.
本文介绍了先前关于基因表达变化机制的著作的扩展内容。这些观点的先前发展导致了一个统一的概念，即由于多种致癌剂导致异染色质改变是导致基因潜在重新表达的关键过程（1）。以下内容在继续探讨基因表达的更精细调控水平之前，仅涉及染色质的结构特征，特别是针对癌细胞而言。DNA甲基化状态被认为是染色质表达中间阶段的一个重要步骤，同时蛋白质乙酰化、磷酸化和甲基化作为改变染色质状态的其他方式。
