Brittenham G M, Farrell D E, Harris J W, Feldman E S, Danish E H, Muir W A, Tripp J H, Bellon E M
N Engl J Med. 1982 Dec 30;307(27):1671-5. doi: 10.1056/NEJM198212303072703.
We made direct noninvasive magnetic measurements of hepatic iron stores with a specially designed superconducting quantum-interference-device (SQUID) susceptometer in 20 normal subjects and in 110 patients with liver disease, iron deficiency, hereditary hemochromatosis, or transfusional iron overload. Magnetic in vivo measurements of liver non-heme iron were closely correlated with chemical in vitro measurements in liver-biopsy specimens (r = 0.98, P less than 10(-5) up to 115 mumol per gram of liver tissue (wet weight) or more. Magnetically determined storage-iron concentrations were below 6.0 mumol per gram in iron-deficient patients and normal men and premenopausal women, but they were raised (9.7 to 31.4 mumol) in 12 of 67 patients with liver disease and were greatly increased (22.9 to 117.7 mumol) in patients with untreated hereditary hemochromatosis or transfusional iron overload. Magnetic measurements of iron stores provide a new quantitative technique for early detection of hereditary hemochromatosis and for rapid evaluation of treatment regimens for transfusional iron overload.
我们使用专门设计的超导量子干涉装置（SQUID）磁强计，对20名正常受试者以及110名患有肝脏疾病、缺铁、遗传性血色素沉着症或输血性铁过载的患者进行了肝脏铁储备的直接无创磁性测量。肝脏非血红素铁的体内磁性测量结果与肝活检标本的体外化学测量结果密切相关（r = 0.98，P小于10^(-5)），测量范围可达每克肝组织（湿重）115微摩尔或更高。在缺铁患者、正常男性和绝经前女性中，通过磁性测定的储存铁浓度低于6.0微摩尔/克，但在67名肝病患者中有12名升高（9.7至31.4微摩尔），在未经治疗的遗传性血色素沉着症或输血性铁过载患者中大幅升高（22.9至117.7微摩尔）。铁储备的磁性测量为遗传性血色素沉着症的早期检测以及输血性铁过载治疗方案的快速评估提供了一种新的定量技术。
