• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

氨鲁米特及其代谢产物N - 乙酰氨鲁米特对牛肾上腺皮质和人胎盘细胞色素P - 450scc的影响。

Effects of aminoglutethiumide and its metabolite, N-acetylaminoglutethimide, on bovine adrenocortical and human placental cytochromes P-450scc.

作者信息

Sheets J J, Vickery L E

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1982 Oct;321(1):70-3. doi: 10.1007/BF00586352.

DOI:10.1007/BF00586352
PMID:7144927
Abstract

The ability of aminoglutethimide to inhibit cholesterol conversion to pregnenolone was lost upon acetylation of the arylamine nitrogen. This appears to be due to failure of N-acetyl-d-aminoglutethimide to bind to cytochrome P-450scc, since it does not produce the altered low spin form of the enzyme formed upon binding of d-aminoglutethimide. These findings provide further evidence for a role of the free arenamine function in aminoglutethimide and related inhibitors.

摘要

氨鲁米特将胆固醇转化为孕烯醇酮的能力在芳胺氮乙酰化后丧失。这似乎是由于N-乙酰-d-氨鲁米特无法与细胞色素P-450scc结合，因为它不会产生在d-氨鲁米特结合后形成的酶的改变的低自旋形式。这些发现为游离芳胺功能在氨鲁米特及相关抑制剂中的作用提供了进一步的证据。

相似文献

1
Effects of aminoglutethiumide and its metabolite, N-acetylaminoglutethimide, on bovine adrenocortical and human placental cytochromes P-450scc.氨鲁米特及其代谢产物N - 乙酰氨鲁米特对牛肾上腺皮质和人胎盘细胞色素P - 450scc的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Oct;321(1):70-3. doi: 10.1007/BF00586352.
2
Inhibition of bovine adrenocortical cytochrome P-450scc by 3,3'-dimethoxybenzidine.
Steroids. 1981 Jan;37(1):91-101. doi: 10.1016/0039-128x(81)90011-8.
3
Cytochrome P-450 of bovine adrenal mitochondria. Ligand binding to two forms resolved by EPR spectroscopy.牛肾上腺线粒体的细胞色素P-450。通过电子顺磁共振光谱解析的两种形式的配体结合。
J Biol Chem. 1976 Jun 25;251(12):3706-15.
4
[Cholesterol-hydroxylating cytochrome P-450 from bovine adrenal cortex mitochondria and human placenta: immunochemical properties and structural characteristics].[来自牛肾上腺皮质线粒体和人胎盘的胆固醇羟化细胞色素P-450：免疫化学性质和结构特征]
Biokhimiia. 1990 May;55(5):865-77.
5
Side-chain specificities of human and bovine cytochromes P-450scc.人及牛细胞色素P-450scc的侧链特异性
Eur J Biochem. 1993 Oct 1;217(1):209-15. doi: 10.1111/j.1432-1033.1993.tb18235.x.
6
Electron paramagnetic resonance studies of the purified cytochrome P-450scc and P-45011beta from bovine adrenocortical mitochondria.
Biochim Biophys Acta. 1979 Mar 27;577(1):170-6. doi: 10.1016/0005-2795(79)90019-9.
7
Modification of enzymatic activity and difference spectra of cytochrome P-450 from various sources by cholesterol side chain cleavage inhibitors.胆固醇侧链裂解抑制剂对不同来源细胞色素P-450酶活性及差光谱的影响
Steroids. 1980 May;35(5):543-59. doi: 10.1016/s0039-128x(80)80008-0.
8
Effects of cholesterol side chain cleavage inhibitors on 11 beta-hydroxylation: linkage of mitochondrial oxygenase systems.胆固醇侧链裂解抑制剂对11β-羟化作用的影响：线粒体加氧酶系统的联系
Steroids. 1981 Jun;37(6):673-9. doi: 10.1016/s0039-128x(81)90209-9.
9
Conversion of cholesterol to pregnenolone mobilizes cytochrome P-450 in the inner membrane of adrenocortical mitochondria: protein rotation study.胆固醇向孕烯醇酮的转化会调动肾上腺皮质线粒体内膜中的细胞色素P-450：蛋白质旋转研究。
J Biochem. 1990 Jan;107(1):97-104. doi: 10.1093/oxfordjournals.jbchem.a123020.
10
Amino-steroids as inhibitors and probes of the active site of cytochrome P-450scc. Effects on the enzyme from different sources.氨基类固醇作为细胞色素P-450scc活性位点的抑制剂和探针。对不同来源酶的影响。
J Steroid Biochem. 1984 Feb;20(2):671-6. doi: 10.1016/0022-4731(84)90141-9.

本文引用的文献

1
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.肝微粒体的一氧化碳结合色素。II. 增溶、纯化及性质
J Biol Chem. 1964 Jul;239:2379-85.
2
3-Methoxybenzidine: a potent inhibitor of cholesterol side chain cleavage cytochrome P-450.
Steroids. 1980 Oct;36(4):473-81. doi: 10.1016/0039-128x(80)90034-3.
3
Inhibition of cholesterol conversion to pregnenolone in submitochondrial particles from bovine adrenal cortex and bovine and human placenta by benzidine derivatives.联苯胺衍生物对牛肾上腺皮质以及牛和人胎盘亚线粒体颗粒中胆固醇转化为孕烯醇酮的抑制作用。
J Steroid Biochem. 1981 Nov;14(11):1217-22. doi: 10.1016/0022-4731(81)90054-6.
4
Less toxic treatment for advanced breast cancer.晚期乳腺癌的低毒治疗方法。
N Engl J Med. 1981 Sep 3;305(10):575-6. doi: 10.1056/NEJM198109033051009.
5
Inhibition of bovine adrenocortical cytochrome P-450scc by 3,3'-dimethoxybenzidine.
Steroids. 1981 Jan;37(1):91-101. doi: 10.1016/0039-128x(81)90011-8.
6
Proximity of the substrate binding site and the heme-iron catalytic site in cytochrome P-450scc.细胞色素P-450侧链裂解酶中底物结合位点与血红素铁催化位点的接近性。
Proc Natl Acad Sci U S A. 1982 Oct;79(19):5773-7. doi: 10.1073/pnas.79.19.5773.
7
Persistent effects of a synthetic androstene derivative on activities of 3-beta-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase in rats.
Endocrinology. 1965 Dec;77(6):1105-18. doi: 10.1210/endo-77-6-1105.
8
The effect of steroid hydroxylase inhibitors on the rate of reduction of adrenal mitochondrial cytochrome P-450.类固醇羟化酶抑制剂对肾上腺线粒体细胞色素P-450还原速率的影响。
Biochem Biophys Res Commun. 1969 Aug 15;36(4):552-8. doi: 10.1016/0006-291x(69)90340-4.
9
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
10
The influence of an anti-steroidogenic drug (aminoglutethimide phosphate) on pregnancy maintenance.一种抗类固醇生成药物（磷酸氨鲁米特）对维持妊娠的影响。
Endocrinology. 1972 May;90(5):1363-70. doi: 10.1210/endo-90-5-1363.