Napier T C, Pirch J H
Neurosci Lett. 1982 Sep 20;32(1):85-90. doi: 10.1016/0304-3940(82)90234-8.
The ability of systemically administered morphine to alter spontaneous and cortically-evoked single unit activity in rat caudate nucleus was assessed in this study. The animals were prepared with permanently implanted microelectrode guide cannulas and cortical stimulating electrodes. For recording sessions, they were pretreated with phenobarbital to allow mounting in the stereotaxic device. Morphine was administered intravenously in incremental doses from 1 to 30 mg/kg. Neither spontaneous activity nor evoked firing was altered in approximately half the units. Spontaneous activity was depressed in 12 of 33 cells and stimulated in 5 of 33 cells. Evoked activity was reduced in 7 of 36 units and enhanced in 9 of 36 cells. A large proportion of the responses to morphine were not reversed by 1 mg/kg naloxone, especially the changes in cortically-evoked firing. These results demonstrate a multiplicity of changes in spontaneous and cortically-evoked activity of caudate nucleus neurons following systemically administered morphine.
本研究评估了全身给药吗啡改变大鼠尾状核自发和皮层诱发单单位活动的能力。给动物永久性植入微电极引导套管和皮层刺激电极。在记录实验中，用苯巴比妥预处理动物以便将其固定在立体定位装置中。以1至30mg/kg的递增剂量静脉注射吗啡。约半数单位的自发活动和诱发放电均未改变。33个细胞中有12个细胞的自发活动受到抑制，33个细胞中有5个细胞的自发活动受到刺激。36个单位中有7个单位的诱发活动降低，36个细胞中有9个细胞的诱发活动增强。对吗啡的大部分反应不能被1mg/kg纳洛酮逆转，尤其是皮层诱发放电的变化。这些结果表明，全身给药吗啡后尾状核神经元的自发和皮层诱发活动存在多种变化。
