Bojoly C, Bouvier M, Bonvoisin B, Lejeune E
Nouv Presse Med. 1982 Sep 18;11(36):2703-6.
The authors have endeavoured to determine the place occupied by mast cells in bone tissue from the mode of action on the bone of their secretion products (metachromatic granules, heparin, prostaglandins), from their proliferation in reaction to some bone diseases (secondary mastocytosis) and from the bone lesions associated with systemic mastocytosis. Metachromatic granules are capable of chelating calcium, and heparin and prostaglandins stimulate bone resorption. However, the role of mast cells in bone remodeling through these mechanisms has not yet been demonstrated. Similarly, the significance of mastocytosis secondary to osteomalacia, renal osteodystrophy and ordinary osteoporosis remains hypothetical. Primary bone mastocytosis produces diffuse or circumscribed osteogenic, osteolytic or mixed lesions. While the pathogenesis of osteolytic forms can readily be explained by the actions of heparin and prostaglandins, that of the osteogenic forms is still mysterious. Finally, the histological profile, and even the nosological profile, of mast cell osteoporosis, a diffuse condition recently individualized, remain undetermined.
作者们试图从肥大细胞分泌产物（异染颗粒、肝素、前列腺素）对骨骼的作用方式、它们在某些骨病（继发性肥大细胞增多症）反应中的增殖情况以及与系统性肥大细胞增多症相关的骨病变来确定肥大细胞在骨组织中所占的地位。异染颗粒能够螯合钙，肝素和前列腺素会刺激骨吸收。然而，肥大细胞通过这些机制在骨重塑中的作用尚未得到证实。同样，继发于骨软化症、肾性骨营养不良和普通骨质疏松症的肥大细胞增多症的意义仍属假设。原发性骨肥大细胞增多症会产生弥漫性或局限性的成骨、溶骨或混合性病变。虽然溶骨型的发病机制可以很容易地用肝素和前列腺素的作用来解释，但成骨型的发病机制仍然不明。最后，肥大细胞性骨质疏松症（一种最近才被确定的弥漫性病症）的组织学特征，甚至疾病分类特征，仍未确定。
