Nightingale S, Bates D, Heath P D, Barron S L
Postgrad Med J. 1982 Sep;58(683):558-9. doi: 10.1136/pgmj.58.683.558.
A 20-year-old woman developed severe persistent vomiting early in pregnancy. In three months she lost 18 kg of body weight and showed the biochemical features of mild hepatic failure. Four days after starting intravenous dextrose and insulin, she developed short-term memory loss, confusion, ataxia, dysarthria, mild left upper motor neurone facial weakness and upbeat nystagmus. Thiamine was given and no further deterioration occurred. The vomiting persisted until intra-uterine fetal death. Thereafter, her medical, neurological and psychological problems gradually improved. The association of hyperemesis gravidarum, intravenous calorie load and Wernicke's encephalopathy is discussed.
一名20岁女性在妊娠早期出现严重持续性呕吐。三个月内她体重减轻了18千克，并表现出轻度肝衰竭的生化特征。开始静脉输注葡萄糖和胰岛素四天后，她出现了短期记忆力丧失、意识模糊、共济失调、构音障碍、轻度左侧上运动神经元性面瘫和上视性眼球震颤。给予了硫胺素，病情未进一步恶化。呕吐一直持续到宫内胎儿死亡。此后，她的医学、神经学和心理学问题逐渐改善。本文讨论了妊娠剧吐、静脉热量负荷与韦尼克脑病之间的关联。
