Geiger J D, Das G, Parmar S S
Pharmacology. 1982;25(4):177-82. doi: 10.1159/000137740.
The clinically relevant interaction between quinidine (3 mg/kg) and digoxin (0.6 mg/kg plus 20 microCi 3H-digoxin) was investigated using unanesthetized and unrestrained guinea pigs for in vivo pharmacokinetic and tissue disposition studies. Quinidine caused a significant elevation of plasma levels of digoxin as early as 5 min after injection, and the increase persisted for at least 8 h. A significant decrease in the volume of distribution for digoxin from 3.6 to 2.7 liters/kg (20%) was observed in quinidine-treated animals. No change was noted in the dominant elimination half-life of digoxin in quinidine-treated animals. The decreased volume of distribution appeared to be due to displacement of digoxin from tissue stores by quinidine as evidenced by decreased tissue to plasma ratios for kidney (41%), intestine (41%), fat (33%), lung (31%), left ventricle (27%), liver (24%), left atrium (22%), right ventricle (21%), right atrium (18%), pancreas (12%), and bladder (-4%) samples.
使用未麻醉且未束缚的豚鼠进行体内药代动力学和组织分布研究，以探究奎尼丁（3毫克/千克）与地高辛（0.6毫克/千克加20微居里³H-地高辛）之间的临床相关相互作用。注射后仅5分钟，奎尼丁就使地高辛的血浆水平显著升高，且这种升高持续至少8小时。在接受奎尼丁治疗的动物中，观察到地高辛的分布容积从3.6升/千克显著降至2.7升/千克（20%）。在接受奎尼丁治疗的动物中，地高辛的主要消除半衰期未发现变化。分布容积的降低似乎是由于奎尼丁将地高辛从组织储存中置换出来，这可通过肾脏（41%）、肠道（41%）、脂肪（33%）、肺（31%）、左心室（27%）、肝脏（24%）、左心房（22%）、右心室（21%）、右心房（18%）、胰腺（12%）和膀胱（-4%）样本的组织与血浆比值降低得到证明。
