Riviere J E
Res Commun Chem Pathol Pharmacol. 1982 Oct;38(1):31-42.
The interpretation of drug clearances derived from plasma pharmacokinetic analysis must take into account the specific physiologic limitations of this method. For aminoglycosides, this includes an insensitivity of total body clearance (C1B), calculated from plasma data alone, to post-filtration proximal renal tubular sequestration of drug. Only clearances utilizing urine excretion data will detect this event. Secondly, the interpretation of plasma and urine drug clearance data must assess the filterability of aminoglycosides at the glomerulus if correct inferences about the extent of tubular reabsorption are to be made.
从血浆药代动力学分析得出的药物清除率的解释必须考虑到该方法特定的生理局限性。对于氨基糖苷类药物，这包括仅根据血浆数据计算的总体清除率（C1B）对滤过后近端肾小管药物潴留不敏感。只有利用尿液排泄数据的清除率才能检测到这一情况。其次，如果要对肾小管重吸收程度做出正确推断，血浆和尿液药物清除率数据的解释必须评估氨基糖苷类药物在肾小球的滤过性。
