Hofmann W
Respir Physiol. 1982 Jul;49(1):115-29. doi: 10.1016/0034-5687(82)90106-2.
Theoretical particle deposition studies for children and youths in practical health physics or medical aerosol therapy require detailed information on alterations of anatomical as well as physiological parameters during postnatal growth. Based on the commonly used anatomical model A of Weibel, assuming regular dichotomy, for an adult human lung, a mathematical model was developed for the calculation of airway parameters, such as geometrical dimensions and number of airways as functions of age. Sometimes widely scattered experimental data obtained by different authors were fitted to analytical functions by a multiregressional procedure. Due to the lack of these data for most of the generations of the anatomical model, theoretical considerations had to be applied. For changes of respiration parameters with progressing age, e.g., tidal volume or respiratory frequency, also experimental data were used. The results of these calculations can then serve as a base for the determination of deposition probabilities in different regions of the human respiratory tract.
在实际健康物理学或医用气雾剂治疗中，针对儿童和青少年的理论粒子沉积研究需要有关出生后生长过程中解剖学和生理学参数变化的详细信息。基于常用的韦贝尔解剖模型A，假设为规则二分法，针对成人肺部，开发了一个数学模型，用于计算气道参数，如作为年龄函数的气道几何尺寸和数量。有时，不同作者获得的广泛分散的实验数据通过多元回归程序拟合到分析函数中。由于解剖模型的大多数代缺乏这些数据，不得不应用理论考量。对于随着年龄增长而变化的呼吸参数，如潮气量或呼吸频率，也使用了实验数据。这些计算结果可作为确定人类呼吸道不同区域沉积概率的基础。
