Monin P, Vert P
Nouv Presse Med. 1978 Sep 23;7(32):2853-4, 2859-61.
Alongside reversible secondary pulmonary arterial hypertension accompanying neonatal respiratory distress, there are primary PAH leading to the persistence of the foetal circulation. This is a true functional neonatal heart disease which may occur alone or be seen in association with another form of neonatal distress such as respiratory distress secondary to the inhalation of amniotic fluid. Any neonatal hypoxaemia irreductible by classical methods should suggest the possibility of persistent pulmonary arteriolar vasoconstriction and lead, in the absence of systemic hypotension, to the administration of vasodilators. These data remain in the preliminary stage and further studies, in particular pharmacological, of these drugs are necessary.
除了伴有新生儿呼吸窘迫的可逆性继发性肺动脉高压外，还有导致胎儿循环持续存在的原发性肺动脉高压。这是一种真正的功能性新生儿心脏病，可单独发生，也可与另一种新生儿窘迫形式同时出现，如羊水吸入继发的呼吸窘迫。任何经传统方法无法缓解的新生儿低氧血症都应提示持续性肺小动脉血管收缩的可能性，并且在无全身性低血压的情况下，应给予血管扩张剂。这些数据仍处于初步阶段，有必要对这些药物进行进一步研究，尤其是药理学研究。
