三甲基锡对化学诱导癫痫发作的影响。

Effect of trimethyltin on chemically-induced seizures.

作者信息

Doctor S V, Costa L G, Murphy S D

出版信息

Toxicol Lett. 1982 Oct;13(3-4):217-23. doi: 10.1016/0378-4274(82)90215-6.

Abstract

The effect of trimethyltin (TMT; 4.26 mg/kg i.p.), at 1 and 14 h following administration, on chemically-induced seizures in mice is reported. At 1 h following administration, TMT decreased seizure responsiveness and protected animals from bicuculline, isonicotinic acid hydrazide (INH) and pentylenetetrazol (PTZ) induced seizures. At 14 h following administration, TMT provided little protection against bicuculline, INH or PTZ induced seizures. Only slight decreases in seizure responsiveness were observed with strychnine induced seizures at either 1 or 14 h. By 16 h following administration, animals exhibited spontaneous tremors and convulsions. The results indicate that TMT exerts a biphasic effect on central nervous system excitability.

摘要

本文报道了腹腔注射三甲基锡（TMT；4.26毫克/千克）后1小时和14小时，其对化学诱导的小鼠癫痫发作的影响。给药后1小时，TMT降低了癫痫反应性，并保护动物免受荷包牡丹碱、异烟肼（INH）和戊四氮（PTZ）诱导的癫痫发作。给药后14小时，TMT对荷包牡丹碱、INH或PTZ诱导的癫痫发作几乎没有保护作用。在1小时或14小时，士的宁诱导的癫痫发作仅观察到癫痫反应性略有降低。给药后16小时，动物出现自发性震颤和惊厥。结果表明，TMT对中枢神经系统兴奋性具有双相作用。