Miretskaia L V, Shvartsman P Ia
Tsitologiia. 1982 Sep;24(9):1056-60.
The cytogenetic activity of formaldehyde was studied in human lymphocytes in vitro. High concentrations of formaldehyde (0.01 mg/ml, 2.5, and 5 mg/l) inhibit mitotic activity of cells to induce polyploidy and chromosome aberrations with high frequency at G2-stage of mitotic cycle. In comparatively low concentrations formaldehyde does not inhibit cell proliferation, and induces chromosome aberrations at G1-S-stages, but not at G2-stage of mitotic cycle. Specific effect of formaldehyde on the distribution of damages pro genome and pro chromosome was also observed.
在体外对人淋巴细胞中甲醛的细胞遗传学活性进行了研究。高浓度甲醛（0.01mg/ml、2.5mg/l和5mg/l）抑制细胞的有丝分裂活性，在有丝分裂周期的G2期高频诱导多倍体和染色体畸变。在相对低浓度下，甲醛不抑制细胞增殖，而是在有丝分裂周期的G1-S期诱导染色体畸变，而在G2期则不会。还观察到甲醛对基因组和染色体损伤分布的特定影响。
