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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Damani L A, Crooks P A, Shaker M S, Caldwell J, D'Souza J, Smith R L

Xenobiotica. 1982 Aug;12(8):527-34. doi: 10.3109/00498258209038931.

The metabolism of [2,6-14C]pyridine in vivo has been investigated in the rat, hamster, mouse, gerbil, rabbit, guinea-pig, cat and man, and the quantitative determination of the various urinary metabolites carried out by radiochromatographic analysis. 2. Unchanged pyridine and its N-methylated metabolite, N-methylpyridinium ion, were determined using a Partisil-10 SCX cation-exchange h.p.l.c. column, whereas the C- and N-oxidation products were assayed by reverse-phase chromatography, using a Partisil-10 ODS column. 3. Most of the species studied produce pyridine N-oxide, N-methylpyridinium ion, 2-pyridone, 3-hydroxypyridine and 4-pyridone as metabolites, but the proportion of the dose excreted as each of these metabolites is species-dependent.

已在大鼠、仓鼠、小鼠、沙鼠、兔子、豚鼠、猫和人类体内研究了[2,6 - 14C]吡啶的代谢情况，并通过放射色谱分析对各种尿液代谢产物进行了定量测定。2. 使用Partisil - 10 SCX阳离子交换高效液相色谱柱测定未变化的吡啶及其N - 甲基化代谢产物N - 甲基吡啶鎓离子，而使用Partisil - 10 ODS柱通过反相色谱法测定C - 和N - 氧化产物。3. 大多数所研究的物种产生吡啶N - 氧化物、N - 甲基吡啶鎓离子、2 - 吡啶酮、3 - 羟基吡啶和4 - 吡啶酮作为代谢产物，但作为这些代谢产物中每一种排出的剂量比例因物种而异。

Damani L A, Crooks P A, Shaker M S, Caldwell J, D'Souza J, Smith R L

Xenobiotica. 1982 Aug;12(8):527-34. doi: 10.3109/00498258209038931.

The metabolism of [2,6-14C]pyridine in vivo has been investigated in the rat, hamster, mouse, gerbil, rabbit, guinea-pig, cat and man, and the quantitative determination of the various urinary metabolites carried out by radiochromatographic analysis. 2. Unchanged pyridine and its N-methylated metabolite, N-methylpyridinium ion, were determined using a Partisil-10 SCX cation-exchange h.p.l.c. column, whereas the C- and N-oxidation products were assayed by reverse-phase chromatography, using a Partisil-10 ODS column. 3. Most of the species studied produce pyridine N-oxide, N-methylpyridinium ion, 2-pyridone, 3-hydroxypyridine and 4-pyridone as metabolites, but the proportion of the dose excreted as each of these metabolites is species-dependent.

已在大鼠、仓鼠、小鼠、沙鼠、兔子、豚鼠、猫和人类体内研究了[2,6 - 14C]吡啶的代谢情况，并通过放射色谱分析对各种尿液代谢产物进行了定量测定。2. 使用Partisil - 10 SCX阳离子交换高效液相色谱柱测定未变化的吡啶及其N - 甲基化代谢产物N - 甲基吡啶鎓离子，而使用Partisil - 10 ODS柱通过反相色谱法测定C - 和N - 氧化产物。3. 大多数所研究的物种产生吡啶N - 氧化物、N - 甲基吡啶鎓离子、2 - 吡啶酮、3 - 羟基吡啶和4 - 吡啶酮作为代谢产物，但作为这些代谢产物中每一种排出的剂量比例因物种而异。