饥饿对大鼠血浆促甲状腺激素昼夜变化的影响。

Effects of starvation on circadian variations of plasma TSH in rats.

作者信息

Hugues J N, Reinberg A, Jordan D, Sebaoun J, Modigliani E, Burger A G

出版信息

Acta Endocrinol (Copenh). 1982 Nov;101(3):403-7. doi: 10.1530/acta.0.1010403.

DOI:10.1530/acta.0.1010403

Abstract

Diurnal fluctuations of plasma TSH were investigated in ad libitum fed rats as well as after a 3 day starvation period in order to study the relationship between the circadian pattern of TSH secretion and nutritional status. Our study showed the persistence of a circadian TSH rhythm after a 3-day starvation without any change in the amplitude of plasma TSH variations. However, the 24 h average plasma TSH levels were significantly lower. A suggestive acrophase occurred at the same period of the day in starved and fed rats. Our results suggest that the control of plasma TSH concentrations and nycthemeral rhythm are not closely related and may even possibly be independent of one another.

摘要

为了研究促甲状腺激素（TSH）分泌的昼夜节律模式与营养状况之间的关系，我们对自由进食的大鼠以及禁食3天的大鼠的血浆TSH昼夜波动情况进行了研究。我们的研究表明，禁食3天后，TSH的昼夜节律依然存在，血浆TSH变化幅度没有任何改变。然而，24小时平均血浆TSH水平显著降低。在饥饿和进食的大鼠中，在一天的同一时间段出现了一个提示性的高峰相位。我们的结果表明，血浆TSH浓度的控制与昼夜节律并非密切相关，甚至可能相互独立。