Dumas G, Charachon R
Acta Otolaryngol. 1982 Sep-Oct;94(3-4):203-12. doi: 10.3109/00016488209128906.
Pregnant guinea pigs were treated with Kanamycin at three different stages of gestation (dating by method of post-partum ovulation). Twenty-nine newborn guinea pigs were tested electrophysiologically by recording the cochlear microphonic potential and the compound action potential from the round window in response to clicks and filtered clicks at 8,000 Hz. Six of the test animals showed the same electrophysiological changes as those found in adult mammals after Kanamycin intoxication. The results suggest a relationship between the ototoxicity of Kanamycin and the onset of auditory function. Cochlear potential and compound action potential were mostly affected when intoxication was performed during the last 15 days of gestation. This study confirms the results previously published by Uziel 1979.
怀孕的豚鼠在妊娠的三个不同阶段（通过产后排卵法确定日期）接受卡那霉素治疗。对29只新生豚鼠进行了电生理学测试，通过记录圆窗对8000Hz的滴答声和滤波后的滴答声的耳蜗微音电位和复合动作电位。6只受试动物表现出与成年哺乳动物卡那霉素中毒后相同的电生理变化。结果表明卡那霉素的耳毒性与听觉功能的开始之间存在关联。当在妊娠的最后15天进行中毒时，耳蜗电位和复合动作电位受影响最大。本研究证实了Uziel于1979年发表的结果。
