Thaulow E, Ihlen H, Kjekshus J, Forfang K, Storstein O
Acta Med Scand. 1982;212(3):131-6. doi: 10.1111/j.0954-6820.1982.tb03184.x.
Twelve patients with congestive heart failure were monitored with invasive and noninvasive techniques to evaluate the effect of vasodilator treatment. During the 18 hours of strict bed rest before administration of prazosin, the hemodynamics improved substantially while only small and transient heModynamic changes were observed after introduction of prazosin. At 6 weeks' control the effect of vasodilator treatment with prazosin, 3 mg x 4, was lost. The beneficial results often credited to vasodilators in studies on congestive heart failure might in part be due to the concomitant bed rest introduced during the monitoring of the patients.
对12例充血性心力衰竭患者采用有创和无创技术进行监测，以评估血管扩张剂治疗的效果。在服用哌唑嗪前严格卧床休息的18小时内，血流动力学有显著改善，而引入哌唑嗪后仅观察到微小且短暂的血流动力学变化。在6周的对照期，服用4次、每次3毫克哌唑嗪的血管扩张剂治疗效果消失。在充血性心力衰竭研究中常归功于血管扩张剂的有益结果，可能部分归因于在患者监测期间同时引入的卧床休息。
