Kvetny J, Orthman-Brask H, Frederiksen P K, Jest P, Jensen E, Jacobsen J G
Acta Med Scand. 1982;212(3):163-6.
The cortisone suppression test and some biochemical tests were evaluated in 13 patients with hypercalcemia due to primary hyperparathyroidism (PHP) and in 10 with hypercalcemia due to a malignant disease. The biochemical tests revealed that serum chloride was significantly raised in patients with PHP compared to patients with malignant diseases, whereas no differences were observed with regard to the serum values of corrected calcium, serum phosphate, chloride/phosphate ratio, HCO3-. Although serum values of parathyroid hormone were higher in patients with PHP, a consider-able overlap was observed between values in the two patient groups. Corrected serum calcium values were significantly suppressed during cortisone administration in patients with malignant disease compared to patients wit PHP, whereas prednisolone had no suppressive effect. The positive predictive value of the test was 80.0% and the negative predictive value 66.7%. We conclude that there is still no entirely reliable method to distinguish between hypercalcemia due to PHP or malignant disease.
对13例原发性甲状旁腺功能亢进症（PHP）所致高钙血症患者和10例恶性疾病所致高钙血症患者进行了可的松抑制试验和一些生化检查。生化检查显示，与恶性疾病患者相比，PHP患者的血清氯显著升高，而校正钙、血清磷酸盐、氯/磷酸盐比值、HCO3-的血清值未见差异。虽然PHP患者的甲状旁腺激素血清值较高，但两组患者的值有相当大的重叠。与PHP患者相比，恶性疾病患者在给予可的松期间校正血清钙值显著降低，而泼尼松龙无抑制作用。该试验的阳性预测值为80.0%，阴性预测值为66.7%。我们得出结论，目前仍没有完全可靠的方法来区分PHP或恶性疾病所致的高钙血症。
