Lahtinen R, Uusitupa M, Kuikka J, Länsimies E
Acta Med Scand. 1982;212(4):201-6. doi: 10.1111/j.0954-6820.1982.tb03201.x.
Measurements of radionuclide first-pass left ventricular ejection fraction (LVEFrn) were carried out in 37 patients receiving doxorubicin and/or daunorubicin treatment for their malignant disease. The validity of the systolic time intervals (STI) and echocardiography (ECHO) in the detection of left ventricular dysfunction was evaluated using LVEFrn as reference method. LVEFrn showed a significant decrease in left ventricular function with cumulative anthracycline doses inpatients with and without previous clinical evidence of cardiovascular disease. A multiple regression analysis showed that the impairment in LVEFrn was significantly correlated with the cumulative anthracycline dose, patient's age and previous cardiovascular disease. In five patients (one without previous cardiac disease, one with coronary artery disease, three with hypertension) the drug had to be withdrawn due to signs or symptoms of cardiac dysfunction. The sensitivity and the specificity of STI and ECHO in the detection of left ventricular dysfunction remained rather low as compared with the results by LVEFrn.
对37例因恶性疾病接受多柔比星和/或柔红霉素治疗的患者进行了放射性核素首次通过左心室射血分数（LVEFrn）测量。以LVEFrn作为参考方法，评估了收缩时间间期（STI）和超声心动图（ECHO）检测左心室功能障碍的有效性。无论有无心血管疾病临床证据的患者，随着蒽环类药物累积剂量增加，LVEFrn显示左心室功能显著下降。多元回归分析表明，LVEFrn受损与蒽环类药物累积剂量、患者年龄及既往心血管疾病显著相关。5例患者（1例无既往心脏病，1例有冠状动脉疾病，3例有高血压）因心脏功能障碍的体征或症状而不得不停药。与LVEFrn的结果相比，STI和ECHO检测左心室功能障碍的敏感性和特异性仍然较低。
