Toivanen P, Lassila O, Eskola J, Martin C, Dieterlen-Lievre F, Gilmour D G
Adv Exp Med Biol. 1982;149:11-7. doi: 10.1007/978-1-4684-9066-4_2.
Lymphocyte development and ontogenetic changes in erythroid cells have been studied in chick-chick yolk sac-embryo chimeras constructed of histoincompatible partners. The results obtained indicate that the early chick yolk sac produces transiently erythroid stem cells whereas definitive erythrocytes are derived from the intraembryonic stem cells. Such a change from the yolk sac-derived cells into embryo-derived cells is not observed in the lymphocytes which are exclusively derived from the embryo-borne stem cells. Experiments with cell transfers from the chimeric yolk sacs demonstrate that erythropoietic and prebursal stem cells migrate from the early embryo to the yolk sac during the second to the seventh day of incubation. The results obtained also exclude the de novo generation of prebursal stem cells in the yolk sac.
在由组织不相容的伙伴构建的鸡-鸡卵黄囊-胚胎嵌合体中，研究了淋巴细胞发育和红细胞系细胞的个体发生变化。所得结果表明，早期鸡卵黄囊产生短暂的红细胞系干细胞，而定型红细胞则来源于胚胎内干细胞。在仅来源于胚胎干细胞的淋巴细胞中未观察到从卵黄囊来源的细胞向胚胎来源的细胞的这种转变。来自嵌合卵黄囊的细胞转移实验表明，在孵化的第二天至第七天期间，造血干细胞和法氏囊前体细胞从早期胚胎迁移到卵黄囊。所得结果也排除了卵黄囊中法氏囊前体细胞的从头产生。
