Gregson R L, Edmondson N A, Plesch B
Adv Exp Med Biol. 1982;149:499-505. doi: 10.1007/978-1-4684-9066-4_70.
Soluble protein antigen (Horseradish peroxidase - HRP) administered to rats intratracheally is predominantly phagocytosed by alveolar macrophages and Type-II pneumonocytes. A proportion, after localization on the lumenal surface of the bronchiolar epithelium is transported across the epithelium via the apical cytoplasm and the intercellular space to the region of the basement membrane. The rate of transfer is faster in the epithelium closer to areas of BALT than elsewhere and in these areas there is further significant penetration below the basement membrane into the BALT tissue to facilitate the contact of antigen and of lymphoid cells. No evidence of alveolar macrophage re-entry to the lymphatic system after phagocytosis of HRP could be seen.
经气管内给予大鼠的可溶性蛋白抗原（辣根过氧化物酶 - HRP）主要被肺泡巨噬细胞和II型肺细胞吞噬。一部分抗原在细支气管上皮的管腔表面定位后，通过顶端细胞质和细胞间空间穿过上皮，到达基底膜区域。在靠近支气管相关淋巴组织（BALT）区域的上皮中，转运速率比其他地方更快，并且在这些区域，抗原在基底膜下方进一步显著渗透到BALT组织中，以促进抗原与淋巴细胞的接触。未观察到HRP被吞噬后肺泡巨噬细胞重新进入淋巴系统的迹象。
