Friedman M J, Okada R D, Ewy G A, Hellman D J
Am Heart J. 1982 Dec;104(6):1303-8. doi: 10.1016/0002-8703(82)90160-0.
In order to assess the effect of hyperthyroidism on systolic and diastolic function of the left ventricle, M-mode echocardiograms and systolic time intervals were obtained in 13 patients while they were clinically hyperthyroid and again when they were euthyroid following radioactive iodine therapy. Echocardiographic tracings of the septum and left ventricular posterior wall were digitized and analyzed to provide the maximum velocity of shortening and maximum velocity of lengthening. These velocities were normalized for left ventricular diastolic dimension. The left ventricular minor axis fractional shortening and the normalized maximum velocity of shortening were both increased during the hyperthyroid state. The normalized maximum velocity of lengthening, a measure of diastolic left ventricular function, was also increased during the hyperthyroid state when compared to the euthyroid state. The preejection period index and the preejection period/left ventricular ejection time ratio were lower when the patients were hyperthyroid than when they were euthyroid. These data confirm the increased inotropic state and demonstrated increased diastolic relaxation velocities of the hyperthyroid left ventricle.
为了评估甲状腺功能亢进对左心室收缩和舒张功能的影响，对13例患者在临床甲状腺功能亢进时以及放射性碘治疗后甲状腺功能正常时分别进行了M型超声心动图检查和收缩期时间间期测定。对室间隔和左心室后壁的超声心动图描记进行数字化处理并分析，以得出最大缩短速度和最大延长速度。这些速度根据左心室舒张末期内径进行了标准化。甲状腺功能亢进状态下，左心室短轴缩短分数和标准化最大缩短速度均增加。与甲状腺功能正常状态相比，甲状腺功能亢进状态下作为左心室舒张功能指标的标准化最大延长速度也增加。射血前期指数以及射血前期/左心室射血时间比值在患者甲状腺功能亢进时低于甲状腺功能正常时。这些数据证实了甲状腺功能亢进时心肌收缩力增强，并表明甲状腺功能亢进的左心室舒张松弛速度增加。
