Fraterrigo C C, Jorgenson J A
Am J Hosp Pharm. 1982 Nov;39(11):1920-3.
The efficiency and accuracy of three methods of preparing i.v. admixtures in small-volume plastic bags were compared. One hundred individual 1-g doses of cephalothin sodium in 50-ml minibags were prepared by each of three methods; the PharmAide Fluid Dispensing System (PAFDS), the Valleylab IV Formulator, and the Viavac vacuum unit, using 20-g, 20-g, and 1-g vials of cephalothin sodium, respectively. For each method, preparation time and cost were recorded. To determine accuracy, a random 10% sample of minibags prepared by each method was assayed for cephalothin concentration by microbiologic assay. The IV Formulator required the least time to prepare 100 doses, followed by the PAFDS and the vacuum unit. Cost data for the three methods were nearly identical, with a difference of only $0.07 per dose between the least and most expensive. The minibags prepared using the vacuum pump and unit-of-use vials were more accurate than those prepared with 20-g vials and the other two methods. However, the initial concentration of the cephalothin sodium vials before transferring to the minibags was not tested. Each method studied was found to have advantages and disadvantages. No one system could be judged best for all situations.
比较了三种在小容量塑料袋中制备静脉内混合液的方法的效率和准确性。分别使用头孢噻吩钠的20克、20克和1克安瓿瓶，通过三种方法中的每一种制备了100个50毫升小袋中含1克剂量的头孢噻吩钠个体；这三种方法分别是PharmAide流体分配系统（PAFDS）、瓦利实验室静脉配方机和Viavac真空装置。对于每种方法，记录了制备时间和成本。为了确定准确性，对每种方法制备的小袋随机抽取10%的样本，通过微生物测定法测定头孢噻吩浓度。静脉配方机制备100剂所需时间最少，其次是PAFDS和真空装置。三种方法的成本数据几乎相同，最便宜和最昂贵的方法之间每剂仅相差0.07美元。使用真空泵和一次性使用安瓿瓶制备的小袋比使用20克安瓿瓶和其他两种方法制备的小袋更准确。然而，在转移到小袋之前头孢噻吩钠安瓿瓶的初始浓度未进行测试。发现所研究的每种方法都有优点和缺点。没有一个系统能被判定在所有情况下都是最佳的。
