Puchstein C, Van Aken H, Anger C, Thyss J, Lawin P
Anasth Intensivther Notfallmed. 1982 Sep;17(5):281-4.
Reliable efficacy and short half-time, combined with the absence of tachyphylaxis and reactive hypertension during and after controlled hypotension should be considered important factors in the use of hypotensive drugs. The vasodilating action of adenosine triphosphate (ATP) was investigated for deliberate hypotension in anaesthesized dogs. During a continuous infusion, in which the dose of ATP was increased from 1 mg/kg . min ATP to 5 mg/kg . min ATP, a stepwise decrease in mean arterial pressure (MAP) and systemic vascular resistance (SVR) could be observed (55%; p less than 0.001). Cardiac output and heart rate increased (p less than 0.05). The physiological intrapulmonary shunt remained unchanged during ATP infusion. ATP acts within 30 sec. and after the end of the infusion haemodynamic parameters returned to control levels within two minutes.
可靠的疗效和较短的半衰期，以及在控制性低血压期间及之后不存在快速耐受性和反应性高血压，应被视为使用降压药物的重要因素。研究了三磷酸腺苷（ATP）在麻醉犬中用于控制性低血压的血管舒张作用。在持续输注过程中，ATP剂量从1毫克/千克·分钟增加至5毫克/千克·分钟，平均动脉压（MAP）和全身血管阻力（SVR）可呈逐步下降（55%；p<0.001）。心输出量和心率增加（p<0.05）。在ATP输注期间，生理性肺内分流保持不变。ATP在30秒内起作用，输注结束后，血流动力学参数在两分钟内恢复至对照水平。
