Yoneda K
Am Rev Respir Dis. 1982 Nov;126(5):893-7. doi: 10.1164/arrd.1982.126.5.893.
There are regional differences in the human lung concerning ventilation, perfusion, and hydrostatic pressure. Structural differences corresponding to these physiologic differences have not been documented. In this study the intercellular junctions of the alveolar-capillary membrane in 3 human lungs were examined by the freeze-fracture technique. The intercellular junctions of the alveolar epithelium revealed neither qualitative nor significant quantitative differences from the upper zone to the lower zone of the lung. There were definite regional differences in the intercellular junctions of the capillary endothelium in the 3 zones of the lungs examined. The number of strands that comprise the tight junctions of the capillary endothelium increases from the upper zone (2.80) to the lower zone (4.99) of the lung.
人类肺部在通气、灌注和流体静压方面存在区域差异。与这些生理差异相对应的结构差异尚未见文献记载。在本研究中，采用冷冻蚀刻技术检查了3例人肺中肺泡-毛细血管膜的细胞间连接。肺泡上皮的细胞间连接从肺的上区到下区既无定性差异，也无显著的定量差异。在所检查的肺的三个区域中，毛细血管内皮的细胞间连接存在明确的区域差异。构成毛细血管内皮紧密连接的嵴线数量从肺的上区（2.80）到下区（4.99）增加。
