Kennedy C, Sakurada O, Shinohara M, Miyaoka M
Ann Neurol. 1982 Oct;12(4):333-40. doi: 10.1002/ana.410120404.
The [14C]deoxyglucose method for quantitative determination of local cerebral glucose utilization was employed in newborn macaque monkeys. Values ranged from a high of 180 mumol/100 gm/min in the inferior colliculus to a low of 14 mumol/100 gm/min in the centrum ovale, a wider range than had been found in this laboratory for pubescent monkeys. Relatively low values in white matter overlapped with the generally higher values in gray matter. Rates for structures in the lower neuraxis were equal to or exceeded those reported for the mature animal, while those above the midbrain were generally lower. The auditory system was unique in having rates equal to, or exceeding, its mature levels in all parts of the pathway including the cortex. In the visual system, subcortical structures were at their mature levels while rates in the cortical areas were variably low; nevertheless, the striate cortex had differential rates marking the various laminae. It was possible to demonstrate the metabolic counterpart of the ocular dominance columns in two newborn animals that had had one eye occluded during the experiment. Rates for white matter were above their mature levels, with the differences being greatest in the brainstem and cerebellum. A high correlation between glucose utilization and local blood flow measured with [14C]antipyrine (r = 0.92) was found.
采用[¹⁴C]脱氧葡萄糖法对新生猕猴的局部脑葡萄糖利用情况进行定量测定。其值范围从下丘的180 μmol/100 g/min的高位到卵圆中心的14 μmol/100 g/min的低位，该范围比本实验室在青春期猴子中发现的范围更宽。白质中的相对低值与灰质中普遍较高的值重叠。低位神经轴结构的速率等于或超过成熟动物报道的速率，而中脑以上的结构速率通常较低。听觉系统的独特之处在于，其在包括皮层在内的通路所有部分的速率等于或超过其成熟水平。在视觉系统中，皮层下结构处于成熟水平，而皮层区域的速率则变化较低；尽管如此，纹状皮层具有标记各层的差异速率。在实验期间一只眼睛被遮挡的两只新生动物中，有可能证明眼优势柱的代谢对应物。白质的速率高于其成熟水平，差异在脑干和小脑中最大。发现葡萄糖利用与用[¹⁴C]安替比林测量的局部血流之间存在高度相关性（r = 0.92）。
